SIRIC Montpellier Cancer and the IRCM, are delighted to announce the installation of the Hyperion XTi, the latest generation imaging mass cytometry system, within its spatial biology facility. The Hyperion XTi uses metal‑tagged antibodies detected by mass spectrometry and can quantify the expression of more than 40 markers per cell, overcoming the usual limitations of fluorescence‑based imaging.
The new system offers three acquisition modes: whole‑slide imaging in preview mode (25 µm), tissue mode (5 µm) and subcellular imaging (1 µm), enabling truly multi‑scale exploration of tissue architecture. Its markedly improved acquisition speed and sensitivity, compared with the previous Hyperion generation, make it possible to generate high‑resolution maps of the tumour microenvironment and to perform genuine single‑cell analyses.
The Hyperion XTi is not available for self‑service use and is operated by the SIMCaT team, which provides an end‑to‑end service from project design through to acquisition and biological interpretation of the data, in close partnership with user teams.
The SIMCaT platform has been supported by funding from the Région Occitanie and the European Union, which have been instrumental in making this advanced technology available to the research and clinical communities.
