The LabUM network EpiGenMed organise a new series of eight prestige seminars in 2023-2024.
The first speaker, Thijn Brummelkamp (NKI, Amsterdam; EMBO Gold medal 2013), a pioneer of functional genomics, will give a conference on the 27th January from 2pm at the new Faculty of Medicine, amphitheatre Marie Curie.
The title of his talk is: Genotype-to-phenotype maps: from genome screens to missing players in cell biology
Thijn Brummelkamp’s group develops and uses genetic tools to identify genes relevant for human disease. Ultradeep mutagenesis of haploid human cells is used to link genes to a compendium of quantitative phenotypes in single cells. These maps shed light on the genetic wiring of human cells, point out ‘missing’ enzymes in cell biology and identify genes relevant for human disease.
Thijn received his MS in biology and did his graduate research at the Netherlands Cancer Institute in the laboratory of Prof. René Bernards. He became a group leader in Cambridge, USA (Whitehead Fellow 2004-2010), and moved his laboratory to the Netherlands Cancer Institute in 2011. He was chosen as one of the world’s top 35 Young Innovators by MIT’s Technology Review magazine (2005) and received EMBO’s gold medal in 2013. As the attached file with a selection of his publications from the last ten years shows, these approaches are enormously powerful and equally applicable to deciphering cellular signalling, identifying viral entry receptors, uncovering determinants of cancer therapy and epigenetic mechanisms. There should be something for everyone. For those who don’t have time to read attached files, here are some highlights!
Carette, J.E. et al (2009). Haploid genetic screens in human cells identify host factors used by pathogens. Science 326, 1231-1235.
Blomen, V.A. et al (2015). Gene essentiality and synthetic lethality in haploid human cells. Science 350(6264) 1092-96
Brockmann, M. et al (2017). Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. Nature 546, 307-311.
Landskron, L. et al (2022). Posttranslational modification of microtubules by the MATCAP detyrosinase. Science 6595, 376-377.
Haahr, P. et al (2022). Actin maturation requires the ACTMAP/C19orf54 protease. Science, 6614, 1533-1537.
After his talk, there will be drinks in the adjacent building and an informal question/answer session for Masters and PhD students and postdocs. Attendance is free but limited to the first 200 arrivals!