Tuesday, January 31, 2022, 11:00 am, IGMM conference room
“Bcl2 family members in colorectal cancer”
Prof. Jan Paul Medema, Cancer Center, Amsterdam
Jan Paul’s group made major contributions in the field of colorectal cancer. Some of their recent publications:
- Di Franco, S., Bianca, P., Sardina, D.S., Turdo, A., Gaggianesi, M., Veschi, V., Nicotra, A., Mangiapane, L.R., Lo Iacono, M., Pillitteri, I., van Hooff, S., Martorana, F., Motta, G., Gulotta, E., Lentini, V.L., Martorana, E., Fiori, M.E., Vieni, S., Bongiorno, M.R., Giannone, G., Giuffrida, D., Memeo, L., Colarossi, L., Mare, M., Vigneri, P., Todaro, M., De Maria, R., Medema, J.P., Stassi, G., 2021. Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery. Nat Commun 12, 5006. https://doi.org/10.1038/s41467-021-25333-9
- Jackstadt, R., van Hooff, S.R., Leach, J.D., Cortes-Lavaud, X., Lohuis, J.O., Ridgway, R.A., Wouters, V.M., Roper, J., Kendall, T.J., Roxburgh, C.S., Horgan, P.G., Nixon, C., Nourse, C., Gunzer, M., Clark, W., Hedley, A., Yilmaz, O.H., Rashid, M., Bailey, P., Biankin, A.V., Campbell, A.D., Adams, D.J., Barry, S.T., Steele, C.W., Medema, J.P., Sansom, O.J., 2019. Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis. Cancer Cell 36, 319-336.e7. https://doi.org/10.1016/j.ccell.2019.08.003
- Ramesh, P., Di Franco, S., Atencia Taboada, L., Zhang, L., Nicotra, A., Stassi, G., Medema, J.P., 2022. BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer. Cell Rep 38, 110374. https://doi.org/10.1016/j.celrep.2022.110374
- Ramesh, P., Lannagan, T.R.M., Jackstadt, R., Atencia Taboada, L., Lansu, N., Wirapati, P., van Hooff, S.R., Dekker, D., Pritchard, J., Kirov, A.B., van Neerven, S.M., Tejpar, S., Kops, G.J.P.L., Sansom, O.J., Medema, J.P., 2021. BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer. Cell Death Differ 28, 3282–3296. https://doi.org/10.1038/s41418-021-00816-w
Contact: Michael Hahne michael.hahne@igmm.cnrs.fr
