Postdoctoral position in cancer biology at the CNRS in Montpellier
Recruiting Team: “tyrosine kinase signaling and oncogenesis”, CRBM UMR5237 CNRS/Montpellier University
Project title: deorphanization of a tumor secreted factor to target metastatic colorectal cancer
Project summary: Protein phosphorylation on tyrosine has evolved as an important mechanism to regulate cell communication in multicellular organisms and its deregulation has a profound impact on human cancer. Our main objective is to understand how perturbation of this phosphorylation-dependent signaling promotes tumor formation. Tumor micro-environmental factors have been recognized as essential determinants involved in promoting tumor metastasis. Here we aim at validating an orphan receptor, for which we demonstrate to mediate the metastatic function of an important tumor secreted factor, as an attractive therapeutic target in colon cancer. Specific aims include analysis of tumor signaling induced by this orphan receptor, assessment of ligand-dependent receptor oncogenicity and development of neutralising antibodies as a novel therapeutic strategy in this human disease.
Techniques: molecular and cellular biology, proteomics, mouse genetics
Candidate profile: highly motivated postdoc in molecular and cellular biology with a strong CV
Funding: Applications will be send to the funding agencies (ARC, Ligue,…) with dead-lines early 2016.
Main publications of the host lab: Chevalier et al, (2016) Nature Commun in the press; Naudin et al (2014) Nature Commun 5, 3159; Sirvent et al (2012) Mol Cell Proteomics 11, 1937; Leroy et al (2009) Cancer Res 69, 2279; Veracini et al (2008) J Cell Biol 11, 603