The post-doc candidate will be assigned a scientific project on the regulation of P53 transcriptional activity in human cancers. A particular focus will be geared toward the involvement of P53 transcription cofactors in chemotherapeutic resistance of human breast cancer models. The research programme will rely on Chromatin Immunoprecipitation followed by DNA-Sequencing (ChIP-Seq), RNA-Seq in biological conditions of P53 activation and/or pharmacological inhibition and finally affinity purification followed by mass spectrometry analysis. The experiments will be carried out in close collaboration with the Montpellier Proteomics Platform and the Montpellier Genomix Platform .
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